A connexin30 mutation rescues hearing and reveals roles for gap junctions in cochlear amplification and micromechanics

Accelerated age-related hearing loss disrupts high-frequency hearing in inbred CD-1 mice. The p.Ala88Val (A88V) mutation in the gene coding for the gap-junction protein connexin30 (Cx30) protects the cochlear basal turn of adult CD-1Cx30(A88V/A88V) mice from degeneration and rescues hearing. Here we...

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Detalles Bibliográficos
Autores principales: Lukashkina, Victoria A., Levic, Snezana, Lukashkin, Andrei N., Strenzke, Nicola, Russell, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321796/
https://www.ncbi.nlm.nih.gov/pubmed/28220769
http://dx.doi.org/10.1038/ncomms14530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321796/
https://www.ncbi.nlm.nih.gov/pubmed/28220769
http://dx.doi.org/10.1038/ncomms14530

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