Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical responses, with highes...

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Detalles Bibliográficos
Autores principales: Lau, Janet, Cheung, Jeanne, Navarro, Armando, Lianoglou, Steve, Haley, Benjamin, Totpal, Klara, Sanders, Laura, Koeppen, Hartmut, Caplazi, Patrick, McBride, Jacqueline, Chiu, Henry, Hong, Rebecca, Grogan, Jane, Javinal, Vincent, Yauch, Robert, Irving, Bryan, Belvin, Marcia, Mellman, Ira, Kim, Jeong M., Schmidt, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321797/
https://www.ncbi.nlm.nih.gov/pubmed/28220772
http://dx.doi.org/10.1038/ncomms14572

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