The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledg...

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Detalles Bibliográficos
Autores principales: Lloret‐Villas, A, Varusai, TM, Juty, N, Laibe, C, Le NovÈre, N, Hermjakob, H, Chelliah, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321808/
https://www.ncbi.nlm.nih.gov/pubmed/28063254
http://dx.doi.org/10.1002/psp4.12155
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author Lloret‐Villas, A
Varusai, TM
Juty, N
Laibe, C
Le NovÈre, N
Hermjakob, H
Chelliah, V
author_facet Lloret‐Villas, A
Varusai, TM
Juty, N
Laibe, C
Le NovÈre, N
Hermjakob, H
Chelliah, V
author_sort Lloret‐Villas, A
collection PubMed
description Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledge and the mechanistic understanding of the major pathological processes implicated in neurodegenerative disorders. We also discuss new directions in the field of neurodegeneration that hold potential for furthering therapeutic interventions and strategies.
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spelling pubmed-53218082017-03-01 The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions Lloret‐Villas, A Varusai, TM Juty, N Laibe, C Le NovÈre, N Hermjakob, H Chelliah, V CPT Pharmacometrics Syst Pharmacol Review Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current state of modeling in the area of neurodegeneration, and objectively compare the gaps between existing clinical knowledge and the mechanistic understanding of the major pathological processes implicated in neurodegenerative disorders. We also discuss new directions in the field of neurodegeneration that hold potential for furthering therapeutic interventions and strategies. John Wiley and Sons Inc. 2017-01-07 2017-02 /pmc/articles/PMC5321808/ /pubmed/28063254 http://dx.doi.org/10.1002/psp4.12155 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Lloret‐Villas, A
Varusai, TM
Juty, N
Laibe, C
Le NovÈre, N
Hermjakob, H
Chelliah, V
The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title_full The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title_fullStr The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title_full_unstemmed The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title_short The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions
title_sort impact of mathematical modeling in understanding the mechanisms underlying neurodegeneration: evolving dimensions and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321808/
https://www.ncbi.nlm.nih.gov/pubmed/28063254
http://dx.doi.org/10.1002/psp4.12155
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