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Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat

Aim: The present study aimed to evaluate the effects of selected straight alkyl chain, hydroxylated chain and branched chain amino acids on gastric adaptive relaxation, as these have previously been shown to have differing effects on gastric emptying. Materials and Methods: Gastric adaptive relaxati...

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Autores principales: Uchida, Masayuki, Iwamoto, Chizuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society of Smooth Muscle Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321853/
https://www.ncbi.nlm.nih.gov/pubmed/27558952
http://dx.doi.org/10.1540/jsmr.52.56
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author Uchida, Masayuki
Iwamoto, Chizuru
author_facet Uchida, Masayuki
Iwamoto, Chizuru
author_sort Uchida, Masayuki
collection PubMed
description Aim: The present study aimed to evaluate the effects of selected straight alkyl chain, hydroxylated chain and branched chain amino acids on gastric adaptive relaxation, as these have previously been shown to have differing effects on gastric emptying. Materials and Methods: Gastric adaptive relaxation was evaluated using a barostat in rats under urethane anesthesia. The pressure within the balloon, introduced from the mouth to the stomach, was changed stepwise from 1 to 8 mmHg. The increased volume just after the increase of balloon pressure was defined as distension-induced gastric adaptive relaxation (accommodation). Amino acids were administered orally or intravenously. Results: As compared with control rats administered with distilled water, those rats that were orally administered amino acids having straight alkyl chain and extra hydroxylated alkyl chain, such as glycine and l-serine, had significantly enhanced gastric adaptive relaxation, but administration of l-alanine and l-threonine did not. Branched chain amino acids, such as l-isoleucine, l-leucine and l-valine, also did not significantly influence gastric adaptive relaxation. Glycine and l-serine showed the same efficacy when administered intravenously. Conclusion: Among the amino acids evaluated in the present study, glycine and l-serine significantly enhanced gastric adaptive relaxation, suggesting that short alkyl chain amino acids may enhance gastric adaptive relaxation as compared with the other amino acids. These findings may suggest that glycine and l-serine would be useful in the therapy of functional dyspepsia, especially for early satiety, because the dysfunction of adaptive relaxation is one of the causes of early satiety.
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spelling pubmed-53218532017-03-24 Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat Uchida, Masayuki Iwamoto, Chizuru J Smooth Muscle Res Original Aim: The present study aimed to evaluate the effects of selected straight alkyl chain, hydroxylated chain and branched chain amino acids on gastric adaptive relaxation, as these have previously been shown to have differing effects on gastric emptying. Materials and Methods: Gastric adaptive relaxation was evaluated using a barostat in rats under urethane anesthesia. The pressure within the balloon, introduced from the mouth to the stomach, was changed stepwise from 1 to 8 mmHg. The increased volume just after the increase of balloon pressure was defined as distension-induced gastric adaptive relaxation (accommodation). Amino acids were administered orally or intravenously. Results: As compared with control rats administered with distilled water, those rats that were orally administered amino acids having straight alkyl chain and extra hydroxylated alkyl chain, such as glycine and l-serine, had significantly enhanced gastric adaptive relaxation, but administration of l-alanine and l-threonine did not. Branched chain amino acids, such as l-isoleucine, l-leucine and l-valine, also did not significantly influence gastric adaptive relaxation. Glycine and l-serine showed the same efficacy when administered intravenously. Conclusion: Among the amino acids evaluated in the present study, glycine and l-serine significantly enhanced gastric adaptive relaxation, suggesting that short alkyl chain amino acids may enhance gastric adaptive relaxation as compared with the other amino acids. These findings may suggest that glycine and l-serine would be useful in the therapy of functional dyspepsia, especially for early satiety, because the dysfunction of adaptive relaxation is one of the causes of early satiety. Japan Society of Smooth Muscle Research 2016-08-25 2016 /pmc/articles/PMC5321853/ /pubmed/27558952 http://dx.doi.org/10.1540/jsmr.52.56 Text en ©2016The Japan Society of Smooth Muscle Research http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Uchida, Masayuki
Iwamoto, Chizuru
Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title_full Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title_fullStr Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title_full_unstemmed Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title_short Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
title_sort influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321853/
https://www.ncbi.nlm.nih.gov/pubmed/27558952
http://dx.doi.org/10.1540/jsmr.52.56
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