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SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation

PURPOSE: To investigate outer retinal tubulation (ORT) using spectral domain optical coherence tomography (SD-OCT) and an adaptive optics scanning laser ophthalmoscope (AOSLO). To document the frequency of ORT in atrophic retinal conditions and quantify ORT dimensions versus adjacent retinal layers....

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Autores principales: King, Brett J., Sapoznik, Kaitlyn A., Elsner, Ann E., Gast, Thomas J., Papay, Joel A., Clark, Christopher A., Burns, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321857/
https://www.ncbi.nlm.nih.gov/pubmed/27984506
http://dx.doi.org/10.1097/OPX.0000000000001031
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author King, Brett J.
Sapoznik, Kaitlyn A.
Elsner, Ann E.
Gast, Thomas J.
Papay, Joel A.
Clark, Christopher A.
Burns, Stephen A.
author_facet King, Brett J.
Sapoznik, Kaitlyn A.
Elsner, Ann E.
Gast, Thomas J.
Papay, Joel A.
Clark, Christopher A.
Burns, Stephen A.
author_sort King, Brett J.
collection PubMed
description PURPOSE: To investigate outer retinal tubulation (ORT) using spectral domain optical coherence tomography (SD-OCT) and an adaptive optics scanning laser ophthalmoscope (AOSLO). To document the frequency of ORT in atrophic retinal conditions and quantify ORT dimensions versus adjacent retinal layers. METHODS: SD-OCT images were reviewed for the presence of retinal atrophy, scarring, and/or exudation. The greatest width of each ORT was quantified. Inner and outer retinal thicknesses adjacent to and within the area of ORT were measured for 18 patients. AOSLO imaged ORTs in five subjects with direct and scattered light imaging. RESULTS: ORT was identified in 47 of 76 subjects (61.8%) and in 65 eyes via SD-OCT in a wide range of conditions and ages, and in peripapillary atrophy. ORTs appeared as finger-like projections in atrophy, seen in the en face images. AOSLO showed some ORTs with bright cones that guide light within atrophic areas. Multiply scattered light mode AOSLO visualized variegated lines (18–35 μm) radiating from ORTs. The ORTs’ width on OCT b-scan images varied from 70 to 509 μm. The inner retina at the ORT was significantly thinner than the adjacent retina, 135 vs.170 μm (P = .004), whereas the outer retina was significantly thicker, 115 vs. 80 μm (P = .03). CONCLUSIONS: ORTs are quite common in eyes with retinal atrophy in various disorders. ORTs demonstrate surviving photoreceptors in tubular structures found within otherwise nonsupportive atrophic areas that lack retinal pigment epithelium and choriocapillaris.
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spelling pubmed-53218572017-03-08 SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation King, Brett J. Sapoznik, Kaitlyn A. Elsner, Ann E. Gast, Thomas J. Papay, Joel A. Clark, Christopher A. Burns, Stephen A. Optom Vis Sci Original Articles PURPOSE: To investigate outer retinal tubulation (ORT) using spectral domain optical coherence tomography (SD-OCT) and an adaptive optics scanning laser ophthalmoscope (AOSLO). To document the frequency of ORT in atrophic retinal conditions and quantify ORT dimensions versus adjacent retinal layers. METHODS: SD-OCT images were reviewed for the presence of retinal atrophy, scarring, and/or exudation. The greatest width of each ORT was quantified. Inner and outer retinal thicknesses adjacent to and within the area of ORT were measured for 18 patients. AOSLO imaged ORTs in five subjects with direct and scattered light imaging. RESULTS: ORT was identified in 47 of 76 subjects (61.8%) and in 65 eyes via SD-OCT in a wide range of conditions and ages, and in peripapillary atrophy. ORTs appeared as finger-like projections in atrophy, seen in the en face images. AOSLO showed some ORTs with bright cones that guide light within atrophic areas. Multiply scattered light mode AOSLO visualized variegated lines (18–35 μm) radiating from ORTs. The ORTs’ width on OCT b-scan images varied from 70 to 509 μm. The inner retina at the ORT was significantly thinner than the adjacent retina, 135 vs.170 μm (P = .004), whereas the outer retina was significantly thicker, 115 vs. 80 μm (P = .03). CONCLUSIONS: ORTs are quite common in eyes with retinal atrophy in various disorders. ORTs demonstrate surviving photoreceptors in tubular structures found within otherwise nonsupportive atrophic areas that lack retinal pigment epithelium and choriocapillaris. Lippincott Williams & Wilkins 2017-03 2016-12-15 /pmc/articles/PMC5321857/ /pubmed/27984506 http://dx.doi.org/10.1097/OPX.0000000000001031 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.on behalf of the American Academy of Optometry This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles
King, Brett J.
Sapoznik, Kaitlyn A.
Elsner, Ann E.
Gast, Thomas J.
Papay, Joel A.
Clark, Christopher A.
Burns, Stephen A.
SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title_full SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title_fullStr SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title_full_unstemmed SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title_short SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation
title_sort sd-oct and adaptive optics imaging of outer retinal tubulation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321857/
https://www.ncbi.nlm.nih.gov/pubmed/27984506
http://dx.doi.org/10.1097/OPX.0000000000001031
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