A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection

The Leishmania donovani nucleoside hydrolase (NH36) and NH A34480 of Leishmania amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against visceral leishmaniasis is mediated by a CD4+ T cell response against its C-terminal domain (F3). Besides this CD4+ Th1 response, pr...

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Detalles Bibliográficos
Autores principales: Alves-Silva, Marcus Vinícius, Nico, Dirlei, Morrot, Alexandre, Palatnik, Marcos, Palatnik-de-Sousa, Clarisa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322207/
https://www.ncbi.nlm.nih.gov/pubmed/28280494
http://dx.doi.org/10.3389/fimmu.2017.00100

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