Yes-Associated Protein Mediates Immune Reprogramming in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated protein (Yap) as a critical regulator of the immunosuppressive microenvironment in both mouse and human PDAC. Within Kras:p53 mutant pancreatic d...

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Detalles Bibliográficos
Autores principales: Murakami, Shigekazu, Shahbazian, David, Surana, Rishi, Zhang, Weiying, Chen, Hengye, Graham, Garrett T., White, Shannon M., Weiner, Louis M., Yi, Chunling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322249/
https://www.ncbi.nlm.nih.gov/pubmed/27546622
http://dx.doi.org/10.1038/onc.2016.288

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