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Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme that mainly represses transcription of target genes via symmetric dimethylation of arginine residues on histones H4R3, H3R8 and H2AR3. Accumulating evidence suggests that PRMT5 may function as an oncogene to drive cancer c...

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Detalles Bibliográficos
Autores principales:	Deng, X, Shao, G, Zhang, H-T, Li, C, Zhang, D, Cheng, L, Elzey, B D, Pili, R, Ratliff, T L, Huang, J, Hu, C-D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322258/ https://www.ncbi.nlm.nih.gov/pubmed/27546619 http://dx.doi.org/10.1038/onc.2016.287

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