A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation

Neuroserpin (NS) mediated inhibition of tissue-type plasminogen activator (tPA) is important for brain development, synapse formation and memory. Aberrations in helix F and β-sheet A movement during inhibition can directly lead to epilepsy or dementia. Conserved W154 residue in a hydrophobic patch b...

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Detalles Bibliográficos
Autores principales: Ali, Mohammad Farhan, Kaushik, Abhinav, Kapil, Charu, Gupta, Dinesh, Jairajpuri, Mohamad Aman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322333/
https://www.ncbi.nlm.nih.gov/pubmed/28230174
http://dx.doi.org/10.1038/srep42987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322333/
https://www.ncbi.nlm.nih.gov/pubmed/28230174
http://dx.doi.org/10.1038/srep42987

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