Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

Ramariolides A–D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed...

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Detalles Bibliográficos
Autores principales: Lehmann, Johannes, Richers, Johannes, Pöthig, Alexander, Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322466/
https://www.ncbi.nlm.nih.gov/pubmed/27847948
http://dx.doi.org/10.1039/c6cc08365j
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author Lehmann, Johannes
Richers, Johannes
Pöthig, Alexander
Sieber, Stephan A.
author_facet Lehmann, Johannes
Richers, Johannes
Pöthig, Alexander
Sieber, Stephan A.
author_sort Lehmann, Johannes
collection PubMed
description Ramariolides A–D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.
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spelling pubmed-53224662017-03-03 Synthesis of ramariolide natural products and discovery of their targets in mycobacteria Lehmann, Johannes Richers, Johannes Pöthig, Alexander Sieber, Stephan A. Chem Commun (Camb) Chemistry Ramariolides A–D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism. Royal Society of Chemistry 2017-01-04 2016-11-11 /pmc/articles/PMC5322466/ /pubmed/27847948 http://dx.doi.org/10.1039/c6cc08365j Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Lehmann, Johannes
Richers, Johannes
Pöthig, Alexander
Sieber, Stephan A.
Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title_full Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title_fullStr Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title_full_unstemmed Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title_short Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
title_sort synthesis of ramariolide natural products and discovery of their targets in mycobacteria
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322466/
https://www.ncbi.nlm.nih.gov/pubmed/27847948
http://dx.doi.org/10.1039/c6cc08365j
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AT pothigalexander synthesisoframariolidenaturalproductsanddiscoveryoftheirtargetsinmycobacteria
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