Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood. Here we identify sex-specific differences in hypothalamic microglial activation via the CX3CL1-CX3CR1 pathway that mediate the resistance of...

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Detalles Bibliográficos
Autores principales: Dorfman, Mauricio D., Krull, Jordan E., Douglass, John D., Fasnacht, Rachael, Lara-Lince, Fernando, Meek, Thomas H., Shi, Xiaogang, Damian, Vincent, Nguyen, Hong T., Matsen, Miles E., Morton, Gregory J., Thaler, Joshua P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322503/
https://www.ncbi.nlm.nih.gov/pubmed/28223698
http://dx.doi.org/10.1038/ncomms14556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322503/
https://www.ncbi.nlm.nih.gov/pubmed/28223698
http://dx.doi.org/10.1038/ncomms14556

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