Cargando…

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood. Here we identify sex-specific differences in hypothalamic microglial activation via the CX3CL1-CX3CR1 pathway that mediate the resistance of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorfman, Mauricio D., Krull, Jordan E., Douglass, John D., Fasnacht, Rachael, Lara-Lince, Fernando, Meek, Thomas H., Shi, Xiaogang, Damian, Vincent, Nguyen, Hong T., Matsen, Miles E., Morton, Gregory J., Thaler, Joshua P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322503/ https://www.ncbi.nlm.nih.gov/pubmed/28223698 http://dx.doi.org/10.1038/ncomms14556

Ejemplares similares

CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding
por: Banerjee, Jineta, et al.
Publicado: (2022)

Defective microglial development in the hippocampus of Cx3cr1 deficient mice
por: Pagani, Francesca, et al.
Publicado: (2015)

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation
por: Douglass, J.D., et al.
Publicado: (2017)

Microglial Cx3cr1 knockout reduces prion disease incubation time in mice
por: Grizenkova, Julia, et al.
Publicado: (2014)

The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation
por: Zhou, Hao, et al.
Publicado: (2020)

Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia
por: Meek, Thomas H., et al.
Publicado: (2015)

CX(3)CR1-CX(3)CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells
por: Lannes, Nils, et al.
Publicado: (2019)

Microglial CX(3)CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX(3)CL1
por: Sellner, Sabine, et al.
Publicado: (2016)

An overlooked subset of Cx3cr1(wt/wt) microglia in the Cx3cr1(CreER-Eyfp/wt) mouse has a repopulation advantage over Cx3cr1(CreER-Eyfp/wt) microglia following microglial depletion
por: Zhou, Kai, et al.
Publicado: (2022)

Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling
por: Roche, Sarah L., et al.
Publicado: (2016)

Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation
por: Chidambaram, Hariharakrishnan, et al.
Publicado: (2020)

PDTC ameliorates neuropathic pain by inhibiting microglial activation via blockage of the TNF a-CX3CR1 pathway
por: Li, Xilei, et al.
Publicado: (2021)

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1‐CX3CR1 signaling in a mouse model of retinitis pigmentosa
por: Zabel, Matthew K., et al.
Publicado: (2016)

Isorhynchophylline Ameliorates Cerebral Ischemia/Reperfusion Injury by Inhibiting CX3CR1-Mediated Microglial Activation and Neuroinflammation
por: Deng, Yuanyuan, et al.
Publicado: (2021)

Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model
por: Zhang, Jingjing, et al.
Publicado: (2018)

CX3CR1 in multiple sclerosis
por: Rivest, Serge
Publicado: (2015)

Role of Fractalkine/CX3CR1 Interaction in Light-Induced Photoreceptor Degeneration through Regulating Retinal Microglial Activation and Migration
por: Zhang, Meng, et al.
Publicado: (2012)

Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1(I249/M280)-expressing retina
por: Church, Kaira A., et al.
Publicado: (2023)

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling
por: Limatola, Cristina, et al.
Publicado: (2014)

The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders
por: Pawelec, Paulina, et al.
Publicado: (2020)

CX3CR1 and malignant progression of glioma
por: Lee, Sungho, et al.
Publicado: (2021)

CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection
por: Chen, Peiqing, et al.
Publicado: (2016)

Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis
por: Wojdasiewicz, Piotr, et al.
Publicado: (2019)

CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation
por: Auffray, Cedric, et al.
Publicado: (2009)

BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production
por: Meek, Thomas H., et al.
Publicado: (2013)

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling
por: Mao, Meng, et al.
Publicado: (2020)

Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems
por: Chamera, Katarzyna, et al.
Publicado: (2020)

Microglia, seen from the CX(3)CR1 angle
por: Wolf, Yochai, et al.
Publicado: (2013)

Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation
por: Bian, Chao, et al.
Publicado: (2015)

Regulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease
por: von Vietinghoff, Sibylle, et al.
Publicado: (2021)

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration
por: Luhmann, Ulrich F.O., et al.
Publicado: (2013)

CX3CR1 Signaling on Monocytes Is Dispensable after Intracerebral Hemorrhage
por: Taylor, Roslyn A., et al.
Publicado: (2014)

Cx3cr1 controls kidney resident macrophage heterogeneity
por: Yashchenko, Alex, et al.
Publicado: (2023)

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease
por: Pabon, Mibel M, et al.
Publicado: (2011)

Semi-Automated Live Tracking of Microglial Activation in CX3CR1(GFP) Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy
por: Frenger, Moritz J., et al.
Publicado: (2021)

Fractalkine (CX3CL1) and Its Receptor CX3CR1: A Promising Therapeutic Target in Chronic Kidney Disease?
por: Cormican, Sarah, et al.
Publicado: (2021)

Hydrogen Sulfide Inhibits the Development of Atherosclerosis with Suppressing CX3CR1 and CX3CL1 Expression
por: Zhang, Huili, et al.
Publicado: (2012)

CX3CL1/CX3CR1 Axis, as the Therapeutic Potential in Renal Diseases: Friend or Foe?
por: Zhuang, Quan, et al.
Publicado: (2017)

Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation
por: Rowinska, Zuzanna, et al.
Publicado: (2017)

CX3CL1–CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis
por: Fernández-Prieto, Marta, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rlnbp2hgpvpscvp56ot29ag20k