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Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism

BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea...

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Autores principales: Makay, Özer, Özçınar, Beyza, Şimşek, Turgay, Arıcı, Cumhur, Güngör, Bülent, Özbaş, Serdar, Akça, Tamer, Emre, Ali Uğur, Karadeniz Çakmak, Güldeniz, Akçay, Müfide, Ünal, Bülent, Girgin, Mustafa, Girgin, Sadullah, Görgülü, Semih, Sezer, Atakan, Karataş, Adem, Özemir, İbrahim Ali, Aksakal, Nihat, Erel, Serap, Uğurlu, M. Ümit, Filiz, Ali İlker, Atalay, Can, Uzunköy, Ali, Deveci, Uğur, Kotan, Çetin, İçöz, Gökhan, Kurt, Yavuz, Kebudi, Abut, Cantürk, N. Zafer, Erbil, Yeşim, Pandev, Rumen, Güllüoğlu, Bahadır M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322512/
https://www.ncbi.nlm.nih.gov/pubmed/28251020
http://dx.doi.org/10.4274/balkanmedj.2015.0865
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author Makay, Özer
Özçınar, Beyza
Şimşek, Turgay
Arıcı, Cumhur
Güngör, Bülent
Özbaş, Serdar
Akça, Tamer
Emre, Ali Uğur
Karadeniz Çakmak, Güldeniz
Akçay, Müfide
Ünal, Bülent
Girgin, Mustafa
Girgin, Sadullah
Görgülü, Semih
Sezer, Atakan
Karataş, Adem
Özemir, İbrahim Ali
Aksakal, Nihat
Erel, Serap
Uğurlu, M. Ümit
Filiz, Ali İlker
Atalay, Can
Uzunköy, Ali
Deveci, Uğur
Kotan, Çetin
İçöz, Gökhan
Kurt, Yavuz
Kebudi, Abut
Cantürk, N. Zafer
Erbil, Yeşim
Pandev, Rumen
Güllüoğlu, Bahadır M.
author_facet Makay, Özer
Özçınar, Beyza
Şimşek, Turgay
Arıcı, Cumhur
Güngör, Bülent
Özbaş, Serdar
Akça, Tamer
Emre, Ali Uğur
Karadeniz Çakmak, Güldeniz
Akçay, Müfide
Ünal, Bülent
Girgin, Mustafa
Girgin, Sadullah
Görgülü, Semih
Sezer, Atakan
Karataş, Adem
Özemir, İbrahim Ali
Aksakal, Nihat
Erel, Serap
Uğurlu, M. Ümit
Filiz, Ali İlker
Atalay, Can
Uzunköy, Ali
Deveci, Uğur
Kotan, Çetin
İçöz, Gökhan
Kurt, Yavuz
Kebudi, Abut
Cantürk, N. Zafer
Erbil, Yeşim
Pandev, Rumen
Güllüoğlu, Bahadır M.
author_sort Makay, Özer
collection PubMed
description BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. STUDY DESIGN: Retrospective, clinical-based multi-centric study of 694 patients with pHPT. METHODS: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. RESULTS: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. CONCLUSION: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT.
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spelling pubmed-53225122017-03-01 Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism Makay, Özer Özçınar, Beyza Şimşek, Turgay Arıcı, Cumhur Güngör, Bülent Özbaş, Serdar Akça, Tamer Emre, Ali Uğur Karadeniz Çakmak, Güldeniz Akçay, Müfide Ünal, Bülent Girgin, Mustafa Girgin, Sadullah Görgülü, Semih Sezer, Atakan Karataş, Adem Özemir, İbrahim Ali Aksakal, Nihat Erel, Serap Uğurlu, M. Ümit Filiz, Ali İlker Atalay, Can Uzunköy, Ali Deveci, Uğur Kotan, Çetin İçöz, Gökhan Kurt, Yavuz Kebudi, Abut Cantürk, N. Zafer Erbil, Yeşim Pandev, Rumen Güllüoğlu, Bahadır M. Balkan Med J Original Article BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. STUDY DESIGN: Retrospective, clinical-based multi-centric study of 694 patients with pHPT. METHODS: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. RESULTS: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. CONCLUSION: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT. Galenos Publishing 2017-01 2017-01-05 /pmc/articles/PMC5322512/ /pubmed/28251020 http://dx.doi.org/10.4274/balkanmedj.2015.0865 Text en © Copyright 2017, Trakya University Faculty of Medicine http://creativecommons.org/licenses/by/2.5/ Balkan Medical Journal
spellingShingle Original Article
Makay, Özer
Özçınar, Beyza
Şimşek, Turgay
Arıcı, Cumhur
Güngör, Bülent
Özbaş, Serdar
Akça, Tamer
Emre, Ali Uğur
Karadeniz Çakmak, Güldeniz
Akçay, Müfide
Ünal, Bülent
Girgin, Mustafa
Girgin, Sadullah
Görgülü, Semih
Sezer, Atakan
Karataş, Adem
Özemir, İbrahim Ali
Aksakal, Nihat
Erel, Serap
Uğurlu, M. Ümit
Filiz, Ali İlker
Atalay, Can
Uzunköy, Ali
Deveci, Uğur
Kotan, Çetin
İçöz, Gökhan
Kurt, Yavuz
Kebudi, Abut
Cantürk, N. Zafer
Erbil, Yeşim
Pandev, Rumen
Güllüoğlu, Bahadır M.
Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title_full Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title_fullStr Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title_full_unstemmed Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title_short Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
title_sort regional clinical and biochemical differences among patients with primary hyperparathyroidism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322512/
https://www.ncbi.nlm.nih.gov/pubmed/28251020
http://dx.doi.org/10.4274/balkanmedj.2015.0865
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