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Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans

Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In the nematode Caenorhabditis elegans, the nuclear receptor DAF-12 acts as a dietary and environmental sensor to orchestrate diverse aspects of dev...

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Autores principales: Tao, Jun, Wu, Qin-Yi, Ma, Yi-Cheng, Chen, Yuan-Li, Zou, Cheng-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322524/
https://www.ncbi.nlm.nih.gov/pubmed/28230214
http://dx.doi.org/10.1038/srep43547
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author Tao, Jun
Wu, Qin-Yi
Ma, Yi-Cheng
Chen, Yuan-Li
Zou, Cheng-Gang
author_facet Tao, Jun
Wu, Qin-Yi
Ma, Yi-Cheng
Chen, Yuan-Li
Zou, Cheng-Gang
author_sort Tao, Jun
collection PubMed
description Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In the nematode Caenorhabditis elegans, the nuclear receptor DAF-12 acts as a dietary and environmental sensor to orchestrate diverse aspects of development, metabolism, and reproduction. Recently, we have reported that DAF-12 together with co-repressor DIN-1S is required for starvation tolerance by promoting fat mobilization. In this report, we found that genetic inactivation of the DAF-12 signaling promoted the production of reactive oxygen species (ROS) during starvation. ROS mediated systemic necrosis, thereby inducing organismal death. The DAF-12/DIN-1S complex up-regulated the expression of antioxidant genes during starvation. The antioxidant enzyme GST-4 in turn suppressed ROS formation, thereby conferring worm survival. Our findings highlight the importance of antioxidant response in starvation tolerance and provide a novel insight into multiple organisms survive and adapt to periods of nutrient deprivation.
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spelling pubmed-53225242017-03-01 Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans Tao, Jun Wu, Qin-Yi Ma, Yi-Cheng Chen, Yuan-Li Zou, Cheng-Gang Sci Rep Article Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In the nematode Caenorhabditis elegans, the nuclear receptor DAF-12 acts as a dietary and environmental sensor to orchestrate diverse aspects of development, metabolism, and reproduction. Recently, we have reported that DAF-12 together with co-repressor DIN-1S is required for starvation tolerance by promoting fat mobilization. In this report, we found that genetic inactivation of the DAF-12 signaling promoted the production of reactive oxygen species (ROS) during starvation. ROS mediated systemic necrosis, thereby inducing organismal death. The DAF-12/DIN-1S complex up-regulated the expression of antioxidant genes during starvation. The antioxidant enzyme GST-4 in turn suppressed ROS formation, thereby conferring worm survival. Our findings highlight the importance of antioxidant response in starvation tolerance and provide a novel insight into multiple organisms survive and adapt to periods of nutrient deprivation. Nature Publishing Group 2017-02-23 /pmc/articles/PMC5322524/ /pubmed/28230214 http://dx.doi.org/10.1038/srep43547 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tao, Jun
Wu, Qin-Yi
Ma, Yi-Cheng
Chen, Yuan-Li
Zou, Cheng-Gang
Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title_full Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title_fullStr Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title_full_unstemmed Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title_short Antioxidant response is a protective mechanism against nutrient deprivation in C. elegans
title_sort antioxidant response is a protective mechanism against nutrient deprivation in c. elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322524/
https://www.ncbi.nlm.nih.gov/pubmed/28230214
http://dx.doi.org/10.1038/srep43547
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