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Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Heterotrimeric guanine-nucleotide-binding proteins (G proteins) serve as molecular switches in signalling pathways, by coupling the activation of cell surface receptors to intracellular responses. Mutations in the G protein α-subunit (Gα) that accelerate guanosine diphosphate (GDP) dissociation caus...

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Detalles Bibliográficos
Autores principales:	Toyama, Yuki, Kano, Hanaho, Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322562/ https://www.ncbi.nlm.nih.gov/pubmed/28223697 http://dx.doi.org/10.1038/ncomms14523

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