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Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass

Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of genes, including genes related to glycemic control, at any stage of life. The epigenetic mechan...

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Autores principales: Sala, Priscila, de Miranda Torrinhas, Raquel Susana Matos, Fonseca, Danielle Cristina, Ravacci, Graziela Rosa, Waitzberg, Dan Linetzky, Giannella-Neto, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322591/
https://www.ncbi.nlm.nih.gov/pubmed/28250848
http://dx.doi.org/10.1186/s13098-017-0214-4
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author Sala, Priscila
de Miranda Torrinhas, Raquel Susana Matos
Fonseca, Danielle Cristina
Ravacci, Graziela Rosa
Waitzberg, Dan Linetzky
Giannella-Neto, Daniel
author_facet Sala, Priscila
de Miranda Torrinhas, Raquel Susana Matos
Fonseca, Danielle Cristina
Ravacci, Graziela Rosa
Waitzberg, Dan Linetzky
Giannella-Neto, Daniel
author_sort Sala, Priscila
collection PubMed
description Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of genes, including genes related to glycemic control, at any stage of life. The epigenetic mechanism underlying obesity and T2D pathogenesis remains poorly understood. Conventional strategies for the treatment of obesity and its comorbidities often have poor long-term adherence, and pharmacological interventions are limited. Bariatric surgery is the most effective current option to treat severe obesity, and Roux-en-Y gastric bypass (RYGB) is the most applied technique worldwide. Epigenetic changes differ depending on the approach used to treat obesity and its associated comorbidities (clinical or surgical). Compared to primary clinical care, bariatric surgery leads to much greater loss of body weight and higher remission rates of T2D and metabolic syndrome, with methylation profiles in promoter regions of genes in obese individuals becoming similar to those of normal-weight individuals. Bariatric surgery can influence DNA methylation in parallel with changes in gene expression pattern. Changes in clinical biomarkers that reflect improvements in glucose and lipid metabolism after RYGB often occur before major weight loss and are coordinated by surgery-induced changes in intestinal hormones. Therefore, the intestine methylation profile would assist in understanding the mechanisms involved in improved glycemic control after bariatric surgery. The main objectives in this area for the future are to identify epigenetic marks that could be used as early indicators of metabolic risk, and to develop treatments able to delay or even reverse these epigenetic changes. Studies that provide the “human epigenetic profile” will be of considerable value to identify tissue-specific epigenetic signatures and their role in the development of chronic diseases. Further studies should apply methods based on global analysis of the genome to identify methylated sites associated with disease and epigenetic marks associated with the remodeling response to bariatric surgery. This review describes the main epigenetic alterations associated with obesity and T2D and the potential role of RYGB in remodeling these changes.
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spelling pubmed-53225912017-03-01 Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass Sala, Priscila de Miranda Torrinhas, Raquel Susana Matos Fonseca, Danielle Cristina Ravacci, Graziela Rosa Waitzberg, Dan Linetzky Giannella-Neto, Daniel Diabetol Metab Syndr Review Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of genes, including genes related to glycemic control, at any stage of life. The epigenetic mechanism underlying obesity and T2D pathogenesis remains poorly understood. Conventional strategies for the treatment of obesity and its comorbidities often have poor long-term adherence, and pharmacological interventions are limited. Bariatric surgery is the most effective current option to treat severe obesity, and Roux-en-Y gastric bypass (RYGB) is the most applied technique worldwide. Epigenetic changes differ depending on the approach used to treat obesity and its associated comorbidities (clinical or surgical). Compared to primary clinical care, bariatric surgery leads to much greater loss of body weight and higher remission rates of T2D and metabolic syndrome, with methylation profiles in promoter regions of genes in obese individuals becoming similar to those of normal-weight individuals. Bariatric surgery can influence DNA methylation in parallel with changes in gene expression pattern. Changes in clinical biomarkers that reflect improvements in glucose and lipid metabolism after RYGB often occur before major weight loss and are coordinated by surgery-induced changes in intestinal hormones. Therefore, the intestine methylation profile would assist in understanding the mechanisms involved in improved glycemic control after bariatric surgery. The main objectives in this area for the future are to identify epigenetic marks that could be used as early indicators of metabolic risk, and to develop treatments able to delay or even reverse these epigenetic changes. Studies that provide the “human epigenetic profile” will be of considerable value to identify tissue-specific epigenetic signatures and their role in the development of chronic diseases. Further studies should apply methods based on global analysis of the genome to identify methylated sites associated with disease and epigenetic marks associated with the remodeling response to bariatric surgery. This review describes the main epigenetic alterations associated with obesity and T2D and the potential role of RYGB in remodeling these changes. BioMed Central 2017-02-22 /pmc/articles/PMC5322591/ /pubmed/28250848 http://dx.doi.org/10.1186/s13098-017-0214-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sala, Priscila
de Miranda Torrinhas, Raquel Susana Matos
Fonseca, Danielle Cristina
Ravacci, Graziela Rosa
Waitzberg, Dan Linetzky
Giannella-Neto, Daniel
Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title_full Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title_fullStr Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title_full_unstemmed Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title_short Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
title_sort tissue-specific methylation profile in obese patients with type 2 diabetes before and after roux-en-y gastric bypass
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322591/
https://www.ncbi.nlm.nih.gov/pubmed/28250848
http://dx.doi.org/10.1186/s13098-017-0214-4
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