Cargando…
Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention
It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, CSC-targeting strategies have not been efficiently translated to the clinic. This...
Autores principales: | Gasch, Claudia, Ffrench, Brendan, O’Leary, John J., Gallagher, Michael F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322629/ https://www.ncbi.nlm.nih.gov/pubmed/28228161 http://dx.doi.org/10.1186/s12943-017-0601-3 |
Ejemplares similares
-
Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention
por: Ffrench, Brendan, et al.
Publicado: (2014) -
CD10(−)/ALDH(−) cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy
por: Ffrench, Brendan, et al.
Publicado: (2017) -
Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC
por: MacDonagh, Lauren, et al.
Publicado: (2017) -
MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype
por: Lynam-Lennon, Niamh, et al.
Publicado: (2016) -
MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer
por: MacDonagh, Lauren, et al.
Publicado: (2021)