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Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the as...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322690/ https://www.ncbi.nlm.nih.gov/pubmed/28250782 http://dx.doi.org/10.4103/1735-1995.193177 |
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author | Javanmard, Shaghayegh Haghjooy Dehghananzadeh, Raheleh Rafiee, Laleh Naji, Hajar Rezayat, Azadeh Sarrafzadegan, Nizal |
author_facet | Javanmard, Shaghayegh Haghjooy Dehghananzadeh, Raheleh Rafiee, Laleh Naji, Hajar Rezayat, Azadeh Sarrafzadegan, Nizal |
author_sort | Javanmard, Shaghayegh Haghjooy |
collection | PubMed |
description | BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the association between G-948T polymorphism of visfatin gene with obesity and lipid profile in a nationally representative sample of Iranian population. MATERIALS AND METHODS: In this case–control study, we assessed 129 randomly selected patients with obesity and 182 healthy normal weight controls from participants of Isfahan Healthy Heart Program. Genomic DNA was isolated from peripheral blood cells, and high-resolution melt polymerase chain reaction was performed to explore the presence of G-948T polymorphism. RESULTS: T carriers “GT + TT” were statistically more frequent in the obese patients than the controls (P = 0.013; odds ratio = 1.9, 95% confidence interval = 1.1–3.1). The serum levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly different between T carriers and GG homozygote genotype (P = 0.03 and 0.02, respectively). CONCLUSION: We concluded that visfatin G-948T polymorphism was correlated with obesity, total cholesterol, and LDL-C levels in our population. |
format | Online Article Text |
id | pubmed-5322690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53226902017-03-01 Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population Javanmard, Shaghayegh Haghjooy Dehghananzadeh, Raheleh Rafiee, Laleh Naji, Hajar Rezayat, Azadeh Sarrafzadegan, Nizal J Res Med Sci Original Article BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the association between G-948T polymorphism of visfatin gene with obesity and lipid profile in a nationally representative sample of Iranian population. MATERIALS AND METHODS: In this case–control study, we assessed 129 randomly selected patients with obesity and 182 healthy normal weight controls from participants of Isfahan Healthy Heart Program. Genomic DNA was isolated from peripheral blood cells, and high-resolution melt polymerase chain reaction was performed to explore the presence of G-948T polymorphism. RESULTS: T carriers “GT + TT” were statistically more frequent in the obese patients than the controls (P = 0.013; odds ratio = 1.9, 95% confidence interval = 1.1–3.1). The serum levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly different between T carriers and GG homozygote genotype (P = 0.03 and 0.02, respectively). CONCLUSION: We concluded that visfatin G-948T polymorphism was correlated with obesity, total cholesterol, and LDL-C levels in our population. Medknow Publications & Media Pvt Ltd 2016-11-02 /pmc/articles/PMC5322690/ /pubmed/28250782 http://dx.doi.org/10.4103/1735-1995.193177 Text en Copyright: © 2016 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Javanmard, Shaghayegh Haghjooy Dehghananzadeh, Raheleh Rafiee, Laleh Naji, Hajar Rezayat, Azadeh Sarrafzadegan, Nizal Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title | Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title_full | Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title_fullStr | Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title_full_unstemmed | Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title_short | Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population |
title_sort | genetic associations of the visfatin g-948t polymorphism with obesity-related metabolic traits in an iranian population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322690/ https://www.ncbi.nlm.nih.gov/pubmed/28250782 http://dx.doi.org/10.4103/1735-1995.193177 |
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