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Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population

BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the as...

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Autores principales: Javanmard, Shaghayegh Haghjooy, Dehghananzadeh, Raheleh, Rafiee, Laleh, Naji, Hajar, Rezayat, Azadeh, Sarrafzadegan, Nizal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322690/
https://www.ncbi.nlm.nih.gov/pubmed/28250782
http://dx.doi.org/10.4103/1735-1995.193177
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author Javanmard, Shaghayegh Haghjooy
Dehghananzadeh, Raheleh
Rafiee, Laleh
Naji, Hajar
Rezayat, Azadeh
Sarrafzadegan, Nizal
author_facet Javanmard, Shaghayegh Haghjooy
Dehghananzadeh, Raheleh
Rafiee, Laleh
Naji, Hajar
Rezayat, Azadeh
Sarrafzadegan, Nizal
author_sort Javanmard, Shaghayegh Haghjooy
collection PubMed
description BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the association between G-948T polymorphism of visfatin gene with obesity and lipid profile in a nationally representative sample of Iranian population. MATERIALS AND METHODS: In this case–control study, we assessed 129 randomly selected patients with obesity and 182 healthy normal weight controls from participants of Isfahan Healthy Heart Program. Genomic DNA was isolated from peripheral blood cells, and high-resolution melt polymerase chain reaction was performed to explore the presence of G-948T polymorphism. RESULTS: T carriers “GT + TT” were statistically more frequent in the obese patients than the controls (P = 0.013; odds ratio = 1.9, 95% confidence interval = 1.1–3.1). The serum levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly different between T carriers and GG homozygote genotype (P = 0.03 and 0.02, respectively). CONCLUSION: We concluded that visfatin G-948T polymorphism was correlated with obesity, total cholesterol, and LDL-C levels in our population.
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spelling pubmed-53226902017-03-01 Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population Javanmard, Shaghayegh Haghjooy Dehghananzadeh, Raheleh Rafiee, Laleh Naji, Hajar Rezayat, Azadeh Sarrafzadegan, Nizal J Res Med Sci Original Article BACKGROUND: Obesity is a global public health problem. Visfatin, as an adipocytokine, is coded by a gene known as nicotinamide phosphoribosyltransferase. So far, results were conflicted regarding correlations of visfatin with obesity and metabolic variables. The present study aimed to explore the association between G-948T polymorphism of visfatin gene with obesity and lipid profile in a nationally representative sample of Iranian population. MATERIALS AND METHODS: In this case–control study, we assessed 129 randomly selected patients with obesity and 182 healthy normal weight controls from participants of Isfahan Healthy Heart Program. Genomic DNA was isolated from peripheral blood cells, and high-resolution melt polymerase chain reaction was performed to explore the presence of G-948T polymorphism. RESULTS: T carriers “GT + TT” were statistically more frequent in the obese patients than the controls (P = 0.013; odds ratio = 1.9, 95% confidence interval = 1.1–3.1). The serum levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly different between T carriers and GG homozygote genotype (P = 0.03 and 0.02, respectively). CONCLUSION: We concluded that visfatin G-948T polymorphism was correlated with obesity, total cholesterol, and LDL-C levels in our population. Medknow Publications & Media Pvt Ltd 2016-11-02 /pmc/articles/PMC5322690/ /pubmed/28250782 http://dx.doi.org/10.4103/1735-1995.193177 Text en Copyright: © 2016 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Javanmard, Shaghayegh Haghjooy
Dehghananzadeh, Raheleh
Rafiee, Laleh
Naji, Hajar
Rezayat, Azadeh
Sarrafzadegan, Nizal
Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title_full Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title_fullStr Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title_full_unstemmed Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title_short Genetic associations of the visfatin G-948T polymorphism with obesity-related metabolic traits in an Iranian population
title_sort genetic associations of the visfatin g-948t polymorphism with obesity-related metabolic traits in an iranian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322690/
https://www.ncbi.nlm.nih.gov/pubmed/28250782
http://dx.doi.org/10.4103/1735-1995.193177
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