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Sorting out adipocyte precursors and their role in physiology and disease
The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322728/ https://www.ncbi.nlm.nih.gov/pubmed/28202540 http://dx.doi.org/10.1101/gad.293704.116 |
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author | Hepler, Chelsea Vishvanath, Lavanya Gupta, Rana K. |
author_facet | Hepler, Chelsea Vishvanath, Lavanya Gupta, Rana K. |
author_sort | Hepler, Chelsea |
collection | PubMed |
description | The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear. Recent studies have identified distinct adipocyte precursor populations that are physiologically regulated and contribute to the development, maintenance, and expansion of adipocyte pools in mice. With new tools available, the properties of adipocyte precursors can now be defined, and the regulation and function of adipose plasticity in development and physiology can be explored. |
format | Online Article Text |
id | pubmed-5322728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53227282017-07-15 Sorting out adipocyte precursors and their role in physiology and disease Hepler, Chelsea Vishvanath, Lavanya Gupta, Rana K. Genes Dev Review The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear. Recent studies have identified distinct adipocyte precursor populations that are physiologically regulated and contribute to the development, maintenance, and expansion of adipocyte pools in mice. With new tools available, the properties of adipocyte precursors can now be defined, and the regulation and function of adipose plasticity in development and physiology can be explored. Cold Spring Harbor Laboratory Press 2017-01-15 /pmc/articles/PMC5322728/ /pubmed/28202540 http://dx.doi.org/10.1101/gad.293704.116 Text en © 2017 Hepler et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Hepler, Chelsea Vishvanath, Lavanya Gupta, Rana K. Sorting out adipocyte precursors and their role in physiology and disease |
title | Sorting out adipocyte precursors and their role in physiology and disease |
title_full | Sorting out adipocyte precursors and their role in physiology and disease |
title_fullStr | Sorting out adipocyte precursors and their role in physiology and disease |
title_full_unstemmed | Sorting out adipocyte precursors and their role in physiology and disease |
title_short | Sorting out adipocyte precursors and their role in physiology and disease |
title_sort | sorting out adipocyte precursors and their role in physiology and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322728/ https://www.ncbi.nlm.nih.gov/pubmed/28202540 http://dx.doi.org/10.1101/gad.293704.116 |
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