Cargando…

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P., Sansom, Owen J., Zender, Lars, Keyes, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322731/ https://www.ncbi.nlm.nih.gov/pubmed/28143833 http://dx.doi.org/10.1101/gad.290635.116

Ejemplares similares

Developing senescence to remodel the embryo
por: Storer, Mekayla, et al.
Publicado: (2014)

Cellular and molecular mechanisms that regulate mammalian digit tip regeneration
por: Storer, Mekayla A., et al.
Publicado: (2020)

To regenerate or not to regenerate: Vertebrate model organisms of regeneration‐competency and ‐incompetency
por: Aztekin, Can, et al.
Publicado: (2022)

A complex secretory program orchestrated by the inflammasome controls paracrine senescence
por: Acosta, Juan Carlos, et al.
Publicado: (2013)

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
por: Ritschka, Birgit, et al.
Publicado: (2020)

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
por: Wang, Wen-Juan, et al.
Publicado: (2017)

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
por: Kumari, Ruchi, et al.
Publicado: (2021)

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer
por: Loo, Tze Mun, et al.
Publicado: (2019)

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer
por: Higashiguchi, Masaya, et al.
Publicado: (2023)

Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
por: Torres-Querol, Coral, et al.
Publicado: (2021)

Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
por: Wan, Mei, et al.
Publicado: (2021)

Cell senescence, the senescence-associated secretory phenotype, and cancers
por: Langhi Prata, Larissa G. P., et al.
Publicado: (2023)

Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration
por: Tomic, Goran, et al.
Publicado: (2018)

Senescence of donor cells impairs fat graft regeneration by suppressing adipogenesis and increasing expression of senescence-associated secretory phenotype factors
por: Chen, Xihang, et al.
Publicado: (2021)

Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche
por: Fatt, Michael P., et al.
Publicado: (2022)

312 Metabolomics Approach to Cellular Senescence: Characterizing the Secretory Phenotype and Metabolism of Irradiation-Induced Senescent Human Pre- Adipocytes
por: Ortiz-Correa, Zinnarky Kiani, et al.
Publicado: (2023)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
por: Herranz, Nicolás, et al.
Publicado: (2015)

In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells
por: Berkenkamp, Birgit, et al.
Publicado: (2014)

Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection
por: Brain, J G, et al.
Publicado: (2013)

Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis
por: De Blander, Hadrien, et al.
Publicado: (2021)

Quantitative Proteomic Analysis of the Senescence‐Associated Secretory Phenotype by Data‐Independent Acquisition
por: Neri, Francesco, et al.
Publicado: (2021)

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
por: Ferreira-Gonzalez, Sofia, et al.
Publicado: (2018)

S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α
por: Su, Yuanyuan, et al.
Publicado: (2019)

hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stability
por: Wang, Hui, et al.
Publicado: (2016)

Wound healing, cellular regeneration and plasticity: the elegans way
por: Vibert, Laura, et al.
Publicado: (2018)

Injury-Induced Cellular Plasticity Drives Intestinal Regeneration
por: Meyer, Anne R., et al.
Publicado: (2021)

Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease
por: Yan, Chi, et al.
Publicado: (2021)

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
por: Saito, Yuki, et al.
Publicado: (2021)

Epimorphic Regeneration of Elastic Cartilage: Morphological Study into the Role of Cellular Senescence
por: Valieva, Yana, et al.
Publicado: (2023)

Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment
por: Petrocelli, Jonathan J., et al.
Publicado: (2023)

MLL1 is essential for the senescence-associated secretory phenotype
por: Capell, Brian C., et al.
Publicado: (2016)

The Role of Senescence-Associated Secretory Phenotype in Bone Loss
por: Zhu, Runjiu, et al.
Publicado: (2022)

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation
por: Huna, Anda, et al.
Publicado: (2023)

Keeping your senescent cells under control
por: Zender, Lars, et al.
Publicado: (2009)

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
por: Guan, Yiting, et al.
Publicado: (2020)

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
por: Shrestha, Niraj, et al.
Publicado: (2023)

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
por: Samakkarnthai, Parinya, et al.
Publicado: (2023)

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm
por: Aschacher, Thomas, et al.
Publicado: (2022)

In vivo partial cellular reprogramming enhances liver plasticity and regeneration
por: Hishida, Tomoaki, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rl5ng5gi1be2dtmq4ncn43gth0