Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Inhibitors targeting the amplification of the fibroblast growth factor receptor 1 (FGFR1) have found success in the treatment of FGFR1-positive squamous cell lung and breast cancers. A secondary mutation of gatekeeper residue (V561M) in the binding site has been linked to the acquired resistance. Re...

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Detalles Bibliográficos
Autores principales: Liang, Donglou, Chen, Qiaowan, Guo, Yujin, Zhang, Ting, Guo, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322841/
https://www.ncbi.nlm.nih.gov/pubmed/28255231
http://dx.doi.org/10.2147/DDDT.S129991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322841/
https://www.ncbi.nlm.nih.gov/pubmed/28255231
http://dx.doi.org/10.2147/DDDT.S129991

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