HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection

Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men...

Descripción completa

Detalles Bibliográficos
Autores principales: Beachler, Daniel C., Waterboer, Tim, Pierce Campbell, Christine M., Ingles, Donna J., Lang Kuhs, Krystle A., Nyitray, Alan G., Hildesheim, Allan, Pawlita, Michael, Kreimer, Aimée R., Giuliano, Anna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322843/
https://www.ncbi.nlm.nih.gov/pubmed/28239675
http://dx.doi.org/10.1016/j.pvr.2016.07.003
_version_ 1782509923232382976
author Beachler, Daniel C.
Waterboer, Tim
Pierce Campbell, Christine M.
Ingles, Donna J.
Lang Kuhs, Krystle A.
Nyitray, Alan G.
Hildesheim, Allan
Pawlita, Michael
Kreimer, Aimée R.
Giuliano, Anna R.
author_facet Beachler, Daniel C.
Waterboer, Tim
Pierce Campbell, Christine M.
Ingles, Donna J.
Lang Kuhs, Krystle A.
Nyitray, Alan G.
Hildesheim, Allan
Pawlita, Michael
Kreimer, Aimée R.
Giuliano, Anna R.
author_sort Beachler, Daniel C.
collection PubMed
description Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0–18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0–8.8%), and 24-month persistent genital HPV16-infection (1/84; 1.2%, 0.0–6.5%). This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition.
format Online
Article
Text
id pubmed-5322843
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-53228432017-12-01 HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection Beachler, Daniel C. Waterboer, Tim Pierce Campbell, Christine M. Ingles, Donna J. Lang Kuhs, Krystle A. Nyitray, Alan G. Hildesheim, Allan Pawlita, Michael Kreimer, Aimée R. Giuliano, Anna R. Papillomavirus Res Article Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0–18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0–8.8%), and 24-month persistent genital HPV16-infection (1/84; 1.2%, 0.0–6.5%). This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition. Elsevier 2016-07-28 /pmc/articles/PMC5322843/ /pubmed/28239675 http://dx.doi.org/10.1016/j.pvr.2016.07.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Beachler, Daniel C.
Waterboer, Tim
Pierce Campbell, Christine M.
Ingles, Donna J.
Lang Kuhs, Krystle A.
Nyitray, Alan G.
Hildesheim, Allan
Pawlita, Michael
Kreimer, Aimée R.
Giuliano, Anna R.
HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title_full HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title_fullStr HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title_full_unstemmed HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title_short HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
title_sort hpv16 e6 seropositivity among cancer-free men with oral, anal or genital hpv16 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322843/
https://www.ncbi.nlm.nih.gov/pubmed/28239675
http://dx.doi.org/10.1016/j.pvr.2016.07.003
work_keys_str_mv AT beachlerdanielc hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT waterboertim hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT piercecampbellchristinem hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT inglesdonnaj hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT langkuhskrystlea hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT nyitrayalang hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT hildesheimallan hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT pawlitamichael hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT kreimeraimeer hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection
AT giulianoannar hpv16e6seropositivityamongcancerfreemenwithoralanalorgenitalhpv16infection

Ejemplares similares