Cargando…

Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India

Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transf...

Descripción completa

Detalles Bibliográficos
Autores principales: Saha, Pabitra, Ganguly, Swagata, Chatterjee, Moytrey, Das, Soumendu Bikash, Kundu, Pratip K., Guha, Subhasish K., Ghosh, Tamal K., Bera, Dilip K., Basu, Nandita, Maji, Ardhendu K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322936/
https://www.ncbi.nlm.nih.gov/pubmed/28187202
http://dx.doi.org/10.1371/journal.pntd.0005391
_version_ 1782509941824684032
author Saha, Pabitra
Ganguly, Swagata
Chatterjee, Moytrey
Das, Soumendu Bikash
Kundu, Pratip K.
Guha, Subhasish K.
Ghosh, Tamal K.
Bera, Dilip K.
Basu, Nandita
Maji, Ardhendu K.
author_facet Saha, Pabitra
Ganguly, Swagata
Chatterjee, Moytrey
Das, Soumendu Bikash
Kundu, Pratip K.
Guha, Subhasish K.
Ghosh, Tamal K.
Bera, Dilip K.
Basu, Nandita
Maji, Ardhendu K.
author_sort Saha, Pabitra
collection PubMed
description Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries.
format Online
Article
Text
id pubmed-5322936
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-53229362017-03-10 Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India Saha, Pabitra Ganguly, Swagata Chatterjee, Moytrey Das, Soumendu Bikash Kundu, Pratip K. Guha, Subhasish K. Ghosh, Tamal K. Bera, Dilip K. Basu, Nandita Maji, Ardhendu K. PLoS Negl Trop Dis Research Article Asymptomatic leishmaniasis may drive the epidemic and an important challenge to reach the goal of joint Visceral Leishmaniasis (VL) elimination initiative taken by three Asian countries. The role of these asymptomatic carriers in disease transmission, prognosis at individual level and rate of transformation to symptomatic VL/Post Kala-azar Dermal Leishmaniasis (PKDL) needs to be evaluated. Asymptomatic cases were diagnosed by active mass survey in eight tribal villages by detecting antileishmanial antibody using rK39 based rapid diagnostic kits and followed up for three years to observe the pattern of sero-conversion and disease transformation. Out of 2890 total population, 2603 were screened. Antileishmanial antibody was detected in 185 individuals of them 96 had a history of VL/PKDL and 89 without such history. Seventy nine such individuals were classified as asymptomatic leishmaniasis and ten as active VL with a ratio of 7.9:1. Out of 79 asymptomatic cases 2 were lost to follow up as they moved to other places. Amongst asymptomatically infected persons, disease transformation in 8/77 (10.39%) and sero-conversion in 62/77 (80.52%) cases were noted. Seven (9.09%) remained sero-positive even after three years. Progression to clinical disease among asymptomatic individuals was taking place at any time up to three years after the baseline survey. If there are no VL /PKDL cases for two or more years, it does not mean that the area is free from leishmaniasis as symptomatic VL or PKDL may appear even after three years, if there are such asymptomatic cases. So, asymptomatic infected individuals need much attention for VL elimination programme that has been initiated by three adjoining endemic countries. Public Library of Science 2017-02-10 /pmc/articles/PMC5322936/ /pubmed/28187202 http://dx.doi.org/10.1371/journal.pntd.0005391 Text en © 2017 Saha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Saha, Pabitra
Ganguly, Swagata
Chatterjee, Moytrey
Das, Soumendu Bikash
Kundu, Pratip K.
Guha, Subhasish K.
Ghosh, Tamal K.
Bera, Dilip K.
Basu, Nandita
Maji, Ardhendu K.
Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title_full Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title_fullStr Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title_full_unstemmed Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title_short Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India
title_sort asymptomatic leishmaniasis in kala-azar endemic areas of malda district, west bengal, india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322936/
https://www.ncbi.nlm.nih.gov/pubmed/28187202
http://dx.doi.org/10.1371/journal.pntd.0005391
work_keys_str_mv AT sahapabitra asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT gangulyswagata asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT chatterjeemoytrey asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT dassoumendubikash asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT kundupratipk asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT guhasubhasishk asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT ghoshtamalk asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT beradilipk asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT basunandita asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia
AT majiardhenduk asymptomaticleishmaniasisinkalaazarendemicareasofmaldadistrictwestbengalindia