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Effects of Na(+) channel blockers on the restitution of refractory period, conduction time, and excitation wavelength in perfused guinea-pig heart
Na(+) channel blockers flecainide and quinidine can increase propensity to ventricular tachyarrhythmia, whereas lidocaine and mexiletine are recognized as safe antiarrhythmics. Clinically, ventricular fibrillation is often precipitated by transient tachycardia that reduces action potential duration,...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322976/ https://www.ncbi.nlm.nih.gov/pubmed/28231318 http://dx.doi.org/10.1371/journal.pone.0172683 |