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Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis

BACKGROUND: High concentrations of methylglyoxal (MGO) cause cytotoxiticy via formation of advanced glycation endproducts (AGEs) and inflammation. MGO is detoxificated enzymatically by glyoxalase-I (Glo-I). The aim of this study was to analyze the role of Glo-I during the development of cirrhosis. M...

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Detalles Bibliográficos
Autores principales:	Hollenbach, Marcus, Thonig, Antje, Pohl, Sabine, Ripoll, Cristina, Michel, Maurice, Zipprich, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322979/ https://www.ncbi.nlm.nih.gov/pubmed/28231326 http://dx.doi.org/10.1371/journal.pone.0171260

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