The presence of CXCR4(+) CD1a(+) cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome

Purpose: Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder characterized by tissue accumulating CD1a(+) histiocytes which frequently carry somatic mutations. Irrespective of mutation status, these LCH-cells display constitutively active kinases belonging to the MAPK pathway. We evaluated,...

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Detalles Bibliográficos
Autores principales: Quispel, Willemijn T., Stegehuis-Kamp, Janine A., Blijleven, Laura, Santos, Susy J., Lourda, Magda, van den Bos, Cor, van Halteren, Astrid G.S., Egeler, R. Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323006/
https://www.ncbi.nlm.nih.gov/pubmed/28255525
http://dx.doi.org/10.1080/2162402X.2015.1084463

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