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Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo
The eukaryotic pre-initiation complex (PIC) bearing the eIF2·GTP·Met-tRNA(i)(Met) ternary complex (TC) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes rearrangement of the PIC from an open, scanning to a closed, arrested conformation. Cryo-EM reconstructions of yeast PIC...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323038/ https://www.ncbi.nlm.nih.gov/pubmed/28169832 http://dx.doi.org/10.7554/eLife.22572 |