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Atomistic simulations indicate the c-subunit ring of the F(1)F(o) ATP synthase is not the mitochondrial permeability transition pore

Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the o...

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Detalles Bibliográficos
Autores principales:	Zhou, Wenchang, Marinelli, Fabrizio, Nief, Corrine, Faraldo-Gómez, José D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323039/ https://www.ncbi.nlm.nih.gov/pubmed/28186490 http://dx.doi.org/10.7554/eLife.23781

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