T-cell epitope strength in WAP-T mouse mammary carcinomas is an important determinant in PD1/PD-L1 immune checkpoint blockade therapy

Using the SV40 transgenic WAP-T/WAP-T(NP) mouse models for mammary carcinomas, we compared the response to immune checkpoint blockade therapy in tumor mice expressing either SV40 T-antigen containing the LCMV NP-epitope (T-Ag(NP) in WAP-T(NP) mice), or the unmodified T-antigen (T-Ag in WAP-T mice)....

Descripción completa

Detalles Bibliográficos
Autores principales: Bruns, Michael, Wanger, Jara, Schumacher, Udo, Deppert, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323098/
https://www.ncbi.nlm.nih.gov/pubmed/27579535
http://dx.doi.org/10.18632/oncotarget.11620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323098/
https://www.ncbi.nlm.nih.gov/pubmed/27579535
http://dx.doi.org/10.18632/oncotarget.11620

Ejemplares similares