CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid leukemia (AML) development and maintenance. We discovered th...

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Detalles Bibliográficos
Autores principales: Saint-Paul, Laetitia, Nguyen, Chi-Hung, Buffière, Anne, de Barros, Jean-Paul Pais, Hammann, Arlette, Landras-Guetta, Corinne, Filomenko, Rodolphe, Chrétien, Marie-Lorraine, Johnson, Pauline, Bastie, Jean-Noël, Delva, Laurent, Quéré, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323116/
https://www.ncbi.nlm.nih.gov/pubmed/27579617
http://dx.doi.org/10.18632/oncotarget.11622

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