HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy

HuR is an mRNA-binding protein whose overexpression in cancer cells has been associated with poor prognosis and resistance to therapy. While reports on HuR overexpression contributing to chemoresistance exist, limited information is available on HuR and radioresistance especially in triple-negative...

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Detalles Bibliográficos
Autores principales: Mehta, Meghna, Basalingappa, Kanthesh, Griffith, James N., Andrade, Daniel, Babu, Anish, Amreddy, Narsireddy, Muralidharan, Ranganayaki, Gorospe, Myriam, Herman, Terence, Ding, Wei-Qun, Ramesh, Rajagopal, Munshi, Anupama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323119/
https://www.ncbi.nlm.nih.gov/pubmed/27588488
http://dx.doi.org/10.18632/oncotarget.11706

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