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Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor

Blocking the interaction of human programmed death 1 (hPD-1) and its ligand hPD-L1 has been a promising immunotherapy in cancer treatment. In this paper, using a computational de novo peptide design method, we designed several hPD-1 binding peptides. The most potent peptide Ar5Y_4 showed a KD value...

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Detalles Bibliográficos
Autores principales:	Li, Qiao, Quan, Lina, Lyu, Jiankun, He, Zenghui, Wang, Xia, Meng, Jiajia, Zhao, Zhenjiang, Zhu, Lili, Liu, Xiaofeng, Li, Honglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323130/ https://www.ncbi.nlm.nih.gov/pubmed/27533458 http://dx.doi.org/10.18632/oncotarget.11274

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