Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit CXCR4 activation may add critical tools to reduce tumor progression, especially in the most aggressive form of the breast cancer...

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Detalles Bibliográficos
Autores principales: Rovito, Daniela, Gionfriddo, Giulia, Barone, Ines, Giordano, Cinzia, Grande, Fedora, De Amicis, Francesca, Lanzino, Marilena, Catalano, Stefania, Andò, Sebastiano, Bonofiglio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323141/
https://www.ncbi.nlm.nih.gov/pubmed/27556298
http://dx.doi.org/10.18632/oncotarget.11371

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