SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development

A major risk factor of developing colorectal cancer (CRC) is the presence of chronic inflammation in the colon. In order to understand how inflammation contributes to CRC development, the present study focused on SHP-2, a tyrosine phosphatase encoded by PTPN11 gene in which polymorphisms have been s...

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Detalles Bibliográficos
Autores principales: Gagné-Sansfaçon, Jessica, Coulombe, Geneviève, Langlois, Marie-Josée, Langlois, Ariane, Paquet, Marilene, Carrier, Julie, Feng, Gen-Sheng, Qu, Cheng-Kui, Rivard, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323184/
https://www.ncbi.nlm.nih.gov/pubmed/27582544
http://dx.doi.org/10.18632/oncotarget.11601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323184/
https://www.ncbi.nlm.nih.gov/pubmed/27582544
http://dx.doi.org/10.18632/oncotarget.11601

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