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SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population

Susceptibility to tuberculosis (TB) is partially dependent on host genetic variability. SP110 and PMP22 are candidate genes identified in this study as associated with human susceptibility to TB. Here we performed an association analysis in a case-control study of a Tibetan population (217 cases and...

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Autores principales: Ren, Guoxia, You, Jiangtao, Gong, Xianfeng, Zhang, Xiucheng, Zhao, Lin, Wei, Xianglan, Jin, Tianbo, Chen, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323218/
https://www.ncbi.nlm.nih.gov/pubmed/27623071
http://dx.doi.org/10.18632/oncotarget.11847
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author Ren, Guoxia
You, Jiangtao
Gong, Xianfeng
Zhang, Xiucheng
Zhao, Lin
Wei, Xianglan
Jin, Tianbo
Chen, Mingwei
author_facet Ren, Guoxia
You, Jiangtao
Gong, Xianfeng
Zhang, Xiucheng
Zhao, Lin
Wei, Xianglan
Jin, Tianbo
Chen, Mingwei
author_sort Ren, Guoxia
collection PubMed
description Susceptibility to tuberculosis (TB) is partially dependent on host genetic variability. SP110 and PMP22 are candidate genes identified in this study as associated with human susceptibility to TB. Here we performed an association analysis in a case-control study of a Tibetan population (217 cases and 383 controls). Using bioinformatics methods, we identified two SNPs in SP110 that may decrease susceptibility to TB (rs4327230, p<0.001, OR: 0.37, 95%CI: 0.25-0.55; rs2114591, p<0.001, OR: 0.59, 95%CI: 0.45-0.78), whereas one SNP in PMP22 appeared to increase TB risk (rs13422, p=0.003, OR: 1.45, 95%CI: 1.14-1.84). SNPs rs4327230 and rs2114591 remained significant after Bonferroni correction (p<0.00178). We found that the “GC” haplotype in SP110 was protective against TB, with a 64% reduction in disease risk. “CA” and “CG” in PMP22 were also associated with a protective effect. Our study indicates there is an association between specific gene polymorphisms and TB risk in a Tibetan population, and may help to identify those TB-affected individuals most susceptible to disease.
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spelling pubmed-53232182017-03-23 SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population Ren, Guoxia You, Jiangtao Gong, Xianfeng Zhang, Xiucheng Zhao, Lin Wei, Xianglan Jin, Tianbo Chen, Mingwei Oncotarget Research Paper Susceptibility to tuberculosis (TB) is partially dependent on host genetic variability. SP110 and PMP22 are candidate genes identified in this study as associated with human susceptibility to TB. Here we performed an association analysis in a case-control study of a Tibetan population (217 cases and 383 controls). Using bioinformatics methods, we identified two SNPs in SP110 that may decrease susceptibility to TB (rs4327230, p<0.001, OR: 0.37, 95%CI: 0.25-0.55; rs2114591, p<0.001, OR: 0.59, 95%CI: 0.45-0.78), whereas one SNP in PMP22 appeared to increase TB risk (rs13422, p=0.003, OR: 1.45, 95%CI: 1.14-1.84). SNPs rs4327230 and rs2114591 remained significant after Bonferroni correction (p<0.00178). We found that the “GC” haplotype in SP110 was protective against TB, with a 64% reduction in disease risk. “CA” and “CG” in PMP22 were also associated with a protective effect. Our study indicates there is an association between specific gene polymorphisms and TB risk in a Tibetan population, and may help to identify those TB-affected individuals most susceptible to disease. Impact Journals LLC 2016-09-06 /pmc/articles/PMC5323218/ /pubmed/27623071 http://dx.doi.org/10.18632/oncotarget.11847 Text en Copyright: © 2016 Ren et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ren, Guoxia
You, Jiangtao
Gong, Xianfeng
Zhang, Xiucheng
Zhao, Lin
Wei, Xianglan
Jin, Tianbo
Chen, Mingwei
SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title_full SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title_fullStr SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title_full_unstemmed SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title_short SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population
title_sort sp110 and pmp22 polymorphisms are associated with tuberculosis risk in a chinese-tibetan population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323218/
https://www.ncbi.nlm.nih.gov/pubmed/27623071
http://dx.doi.org/10.18632/oncotarget.11847
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