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PinX1: structure, regulation and its functions in cancer
PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene located at human chromosome 8p23, playing a vital role in maintaining telomeres length and chromosome stability. It has been demonstrated to be involved in tumor genesis and progression in most malignancies. However, some re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323232/ https://www.ncbi.nlm.nih.gov/pubmed/27556185 http://dx.doi.org/10.18632/oncotarget.11411 |
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author | Li, Hai-Long Song, Jun Yong, Hong-Mei Hou, Ping-Fu Chen, Yan-Su Song, Wen-Bo Bai, Jin Zheng, Jun-Nian |
author_facet | Li, Hai-Long Song, Jun Yong, Hong-Mei Hou, Ping-Fu Chen, Yan-Su Song, Wen-Bo Bai, Jin Zheng, Jun-Nian |
author_sort | Li, Hai-Long |
collection | PubMed |
description | PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene located at human chromosome 8p23, playing a vital role in maintaining telomeres length and chromosome stability. It has been demonstrated to be involved in tumor genesis and progression in most malignancies. However, some researches showed opposing molecular status of PinX1 gene and its expression patterns in several other types of tumors. The pathogenic mechanism of PinX1 expression in human malignancy is not yet clear. Moreover, emerging evidence suggest that PinX1 (especially its TID domain) might be a potential new target cancer treatment. Therefore, PinX1 may be a new potential diagnostic biomarker and therapeutic target for human cancers, and may play different roles in different human cancers. The functions and the mechanisms of PinX1 in various human cancers remain unclear, suggesting the necessity of further extensive works of its role in tumor genesis and progression. |
format | Online Article Text |
id | pubmed-5323232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53232322017-03-23 PinX1: structure, regulation and its functions in cancer Li, Hai-Long Song, Jun Yong, Hong-Mei Hou, Ping-Fu Chen, Yan-Su Song, Wen-Bo Bai, Jin Zheng, Jun-Nian Oncotarget Review PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene located at human chromosome 8p23, playing a vital role in maintaining telomeres length and chromosome stability. It has been demonstrated to be involved in tumor genesis and progression in most malignancies. However, some researches showed opposing molecular status of PinX1 gene and its expression patterns in several other types of tumors. The pathogenic mechanism of PinX1 expression in human malignancy is not yet clear. Moreover, emerging evidence suggest that PinX1 (especially its TID domain) might be a potential new target cancer treatment. Therefore, PinX1 may be a new potential diagnostic biomarker and therapeutic target for human cancers, and may play different roles in different human cancers. The functions and the mechanisms of PinX1 in various human cancers remain unclear, suggesting the necessity of further extensive works of its role in tumor genesis and progression. Impact Journals LLC 2016-08-19 /pmc/articles/PMC5323232/ /pubmed/27556185 http://dx.doi.org/10.18632/oncotarget.11411 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Li, Hai-Long Song, Jun Yong, Hong-Mei Hou, Ping-Fu Chen, Yan-Su Song, Wen-Bo Bai, Jin Zheng, Jun-Nian PinX1: structure, regulation and its functions in cancer |
title | PinX1: structure, regulation and its functions in cancer |
title_full | PinX1: structure, regulation and its functions in cancer |
title_fullStr | PinX1: structure, regulation and its functions in cancer |
title_full_unstemmed | PinX1: structure, regulation and its functions in cancer |
title_short | PinX1: structure, regulation and its functions in cancer |
title_sort | pinx1: structure, regulation and its functions in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323232/ https://www.ncbi.nlm.nih.gov/pubmed/27556185 http://dx.doi.org/10.18632/oncotarget.11411 |
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