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The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias

The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to induce resistance to chemotherapy and to mediate invasion and metastasis. NF-κB is recruited through different mechanisms i...

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Autores principales: Carrà, Giovanna, Torti, Davide, Crivellaro, Sabrina, Panuzzo, Cristina, Taulli, Riccardo, Cilloni, Daniela, Guerrasio, Angelo, Saglio, Giuseppe, Morotti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323234/
https://www.ncbi.nlm.nih.gov/pubmed/27563822
http://dx.doi.org/10.18632/oncotarget.11507
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author Carrà, Giovanna
Torti, Davide
Crivellaro, Sabrina
Panuzzo, Cristina
Taulli, Riccardo
Cilloni, Daniela
Guerrasio, Angelo
Saglio, Giuseppe
Morotti, Alessandro
author_facet Carrà, Giovanna
Torti, Davide
Crivellaro, Sabrina
Panuzzo, Cristina
Taulli, Riccardo
Cilloni, Daniela
Guerrasio, Angelo
Saglio, Giuseppe
Morotti, Alessandro
author_sort Carrà, Giovanna
collection PubMed
description The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to induce resistance to chemotherapy and to mediate invasion and metastasis. NF-κB is recruited through different mechanisms involving either canonical (RelA/p50) or non-canonical pathways (RelB/p50 or RelB/p52), which transduce the signals originated from growth-factors, cytokines, oncogenic stress and DNA damage, bacterial and viral products or other stimuli. The pharmacological inhibition of the NF-κB pathway has clearly been associated with significant clinical activity in different cancers. Almost 20 years ago, NF-κB was described as an essential modulator of BCR-ABL signaling in Chronic Myeloid Leukemia and Philadelphia-positive Acute Lymphoblastic Leukemia. This review summarizes the role of NF-κB in BCR-ABL-mediated leukemogenesis and provides new insights on the long lasting BCR-ABL/NF-κB connection.
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spelling pubmed-53232342017-03-23 The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias Carrà, Giovanna Torti, Davide Crivellaro, Sabrina Panuzzo, Cristina Taulli, Riccardo Cilloni, Daniela Guerrasio, Angelo Saglio, Giuseppe Morotti, Alessandro Oncotarget Review The Nuclear Factor-kappa B (NF-κB) family of transcription factors plays a key role in cancer pathogenesis due to the ability to promote cellular proliferation and survival, to induce resistance to chemotherapy and to mediate invasion and metastasis. NF-κB is recruited through different mechanisms involving either canonical (RelA/p50) or non-canonical pathways (RelB/p50 or RelB/p52), which transduce the signals originated from growth-factors, cytokines, oncogenic stress and DNA damage, bacterial and viral products or other stimuli. The pharmacological inhibition of the NF-κB pathway has clearly been associated with significant clinical activity in different cancers. Almost 20 years ago, NF-κB was described as an essential modulator of BCR-ABL signaling in Chronic Myeloid Leukemia and Philadelphia-positive Acute Lymphoblastic Leukemia. This review summarizes the role of NF-κB in BCR-ABL-mediated leukemogenesis and provides new insights on the long lasting BCR-ABL/NF-κB connection. Impact Journals LLC 2016-08-22 /pmc/articles/PMC5323234/ /pubmed/27563822 http://dx.doi.org/10.18632/oncotarget.11507 Text en Copyright: © 2016 Carrà et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Carrà, Giovanna
Torti, Davide
Crivellaro, Sabrina
Panuzzo, Cristina
Taulli, Riccardo
Cilloni, Daniela
Guerrasio, Angelo
Saglio, Giuseppe
Morotti, Alessandro
The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title_full The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title_fullStr The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title_full_unstemmed The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title_short The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias
title_sort bcr-abl/nf-κb signal transduction network: a long lasting relationship in philadelphia positive leukemias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323234/
https://www.ncbi.nlm.nih.gov/pubmed/27563822
http://dx.doi.org/10.18632/oncotarget.11507
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