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Intestinal barrier integrity and function in infants with cholestasis
BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intesti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association for the Study of Intestinal Diseases
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323301/ https://www.ncbi.nlm.nih.gov/pubmed/28239322 http://dx.doi.org/10.5217/ir.2017.15.1.118 |
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author | Abu Faddan, Nagla H. Sherif, Tahra M. K. Mohammed, Omnia A. Nasif, Khalid A. El Gezawy, Ebtesam M. |
author_facet | Abu Faddan, Nagla H. Sherif, Tahra M. K. Mohammed, Omnia A. Nasif, Khalid A. El Gezawy, Ebtesam M. |
author_sort | Abu Faddan, Nagla H. |
collection | PubMed |
description | BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability. METHODS: This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactate were measured in all subjects. RESULTS: Both groups of patients with neonatal hepatitis and biliary atresia showed significantly higher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the cases and controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were found in the cholestatic infants. CONCLUSIONS: The intestinal epithelial barrier integrity is breached nearly in all parts of the intestine in infants with cholestasis. Further research is recommended to determine the impact of this finding on the management of these infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for further research. |
format | Online Article Text |
id | pubmed-5323301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Association for the Study of Intestinal Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-53233012017-02-24 Intestinal barrier integrity and function in infants with cholestasis Abu Faddan, Nagla H. Sherif, Tahra M. K. Mohammed, Omnia A. Nasif, Khalid A. El Gezawy, Ebtesam M. Intest Res Original Article BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability. METHODS: This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactate were measured in all subjects. RESULTS: Both groups of patients with neonatal hepatitis and biliary atresia showed significantly higher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the cases and controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were found in the cholestatic infants. CONCLUSIONS: The intestinal epithelial barrier integrity is breached nearly in all parts of the intestine in infants with cholestasis. Further research is recommended to determine the impact of this finding on the management of these infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for further research. Korean Association for the Study of Intestinal Diseases 2017-01 2017-01-31 /pmc/articles/PMC5323301/ /pubmed/28239322 http://dx.doi.org/10.5217/ir.2017.15.1.118 Text en © Copyright 2017. Korean Association for the Study of Intestinal Diseases. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Abu Faddan, Nagla H. Sherif, Tahra M. K. Mohammed, Omnia A. Nasif, Khalid A. El Gezawy, Ebtesam M. Intestinal barrier integrity and function in infants with cholestasis |
title | Intestinal barrier integrity and function in infants with cholestasis |
title_full | Intestinal barrier integrity and function in infants with cholestasis |
title_fullStr | Intestinal barrier integrity and function in infants with cholestasis |
title_full_unstemmed | Intestinal barrier integrity and function in infants with cholestasis |
title_short | Intestinal barrier integrity and function in infants with cholestasis |
title_sort | intestinal barrier integrity and function in infants with cholestasis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323301/ https://www.ncbi.nlm.nih.gov/pubmed/28239322 http://dx.doi.org/10.5217/ir.2017.15.1.118 |
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