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Intestinal barrier integrity and function in infants with cholestasis

BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intesti...

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Autores principales: Abu Faddan, Nagla H., Sherif, Tahra M. K., Mohammed, Omnia A., Nasif, Khalid A., El Gezawy, Ebtesam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323301/
https://www.ncbi.nlm.nih.gov/pubmed/28239322
http://dx.doi.org/10.5217/ir.2017.15.1.118
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author Abu Faddan, Nagla H.
Sherif, Tahra M. K.
Mohammed, Omnia A.
Nasif, Khalid A.
El Gezawy, Ebtesam M.
author_facet Abu Faddan, Nagla H.
Sherif, Tahra M. K.
Mohammed, Omnia A.
Nasif, Khalid A.
El Gezawy, Ebtesam M.
author_sort Abu Faddan, Nagla H.
collection PubMed
description BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability. METHODS: This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactate were measured in all subjects. RESULTS: Both groups of patients with neonatal hepatitis and biliary atresia showed significantly higher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the cases and controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were found in the cholestatic infants. CONCLUSIONS: The intestinal epithelial barrier integrity is breached nearly in all parts of the intestine in infants with cholestasis. Further research is recommended to determine the impact of this finding on the management of these infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for further research.
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spelling pubmed-53233012017-02-24 Intestinal barrier integrity and function in infants with cholestasis Abu Faddan, Nagla H. Sherif, Tahra M. K. Mohammed, Omnia A. Nasif, Khalid A. El Gezawy, Ebtesam M. Intest Res Original Article BACKGROUND/AIMS: The safety of the human body is maintained by effective monitoring of the mucosal surface integrity and protection against potentially harmful compounds. This function of the gut called intestinal barrier function can be affected by cholestasis and the absence of bile in the intestinal lumen. We aimed to determine whether the gut barrier integrity is impaired in infants with cholestasis by evaluation of the intestinal fatty acid binding proteins (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of intestinal epithelial cell damage and plasma D-lactate level as a marker of gut wall permeability. METHODS: This case-control study included 53 infants with cholestasis and 29 controls. Serum levels of I-FABP, I-BABP, and D-lactate were measured in all subjects. RESULTS: Both groups of patients with neonatal hepatitis and biliary atresia showed significantly higher levels of I-FABP and I-BABP than the controls. There were no differences in the serum D-lactate level between the cases and controls. There was no difference between the two groups of patients (I and II) regarding any of the parameters studied. No significant correlations between serum levels of I-FABP, I-BABP, or D-lactate and total or direct bilirubin levels were found in the cholestatic infants. CONCLUSIONS: The intestinal epithelial barrier integrity is breached nearly in all parts of the intestine in infants with cholestasis. Further research is recommended to determine the impact of this finding on the management of these infants. The relationship between physical intestinal barrier damage and its functional failure remains subject for further research. Korean Association for the Study of Intestinal Diseases 2017-01 2017-01-31 /pmc/articles/PMC5323301/ /pubmed/28239322 http://dx.doi.org/10.5217/ir.2017.15.1.118 Text en © Copyright 2017. Korean Association for the Study of Intestinal Diseases. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Abu Faddan, Nagla H.
Sherif, Tahra M. K.
Mohammed, Omnia A.
Nasif, Khalid A.
El Gezawy, Ebtesam M.
Intestinal barrier integrity and function in infants with cholestasis
title Intestinal barrier integrity and function in infants with cholestasis
title_full Intestinal barrier integrity and function in infants with cholestasis
title_fullStr Intestinal barrier integrity and function in infants with cholestasis
title_full_unstemmed Intestinal barrier integrity and function in infants with cholestasis
title_short Intestinal barrier integrity and function in infants with cholestasis
title_sort intestinal barrier integrity and function in infants with cholestasis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323301/
https://www.ncbi.nlm.nih.gov/pubmed/28239322
http://dx.doi.org/10.5217/ir.2017.15.1.118
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