Rho-Associated Kinase 1 (ROCK1) inhibition is Synthetically Lethal with Von Hippel Lindau (VHL) Deficiency in Clear Cell Renal Cell Carcinoma (CC-RCC)

Clear Cell Renal Cell Carcinoma (CC-RCC) is the most lethal of all genitourinary cancers. The functional loss of the von Hippel-Lindau (VHL) gene occurs in 90% of CC-RCC, driving cancer progression. The objective of this study was to identify chemical compounds that are synthetically lethal with VHL...

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Detalles Bibliográficos
Autores principales: Thompson, Jordan M., Nguyen, Quy H., Singh, Manpreet, Pavesic, Matthew W., Nesterenko, Irina, Nelson, Luke J., Liao, Alicia C., Razorenova, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323317/
https://www.ncbi.nlm.nih.gov/pubmed/27841867
http://dx.doi.org/10.1038/onc.2016.272

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