Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants

The synthetically produced cyclic peptides solnatide (a.k.a. TIP or AP301) and its congener AP318, whose molecular structures mimic the lectin-like domain of human tumor necrosis factor (TNF), have been shown to activate the epithelial sodium channel (ENaC) in various cell- and animal-based studies....

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Detalles Bibliográficos
Autores principales: Willam, Anita, Aufy, Mohammed, Tzotzos, Susan, Evanzin, Heinrich, Chytracek, Sabine, Geppert, Sabrina, Fischer, Bernhard, Fischer, Hendrik, Pietschmann, Helmut, Czikora, Istvan, Lucas, Rudolf, Lemmens-Gruber, Rosa, Shabbir, Waheed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323398/
https://www.ncbi.nlm.nih.gov/pubmed/28286482
http://dx.doi.org/10.3389/fphar.2017.00085

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