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(68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients
BACKGROUND: To report on imaging findings using (68)Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS: (68)Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323468/ https://www.ncbi.nlm.nih.gov/pubmed/27822700 http://dx.doi.org/10.1007/s00259-016-3563-6 |
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author | Sathekge, Mike Lengana, Thabo Modiselle, Moshe Vorster, Mariza Zeevaart, JanRijn Maes, Alex Ebenhan, Thomas Van de Wiele, Christophe |
author_facet | Sathekge, Mike Lengana, Thabo Modiselle, Moshe Vorster, Mariza Zeevaart, JanRijn Maes, Alex Ebenhan, Thomas Van de Wiele, Christophe |
author_sort | Sathekge, Mike |
collection | PubMed |
description | BACKGROUND: To report on imaging findings using (68)Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS: (68)Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS: Out of 81 tumor lesions identified, 84% were identified on (68)Ga-PSMA-HBED-CC PET. (68)Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and (68)Ga-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015). CONCLUSIONS: (68)Ga-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry. |
format | Online Article Text |
id | pubmed-5323468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-53234682017-03-09 (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients Sathekge, Mike Lengana, Thabo Modiselle, Moshe Vorster, Mariza Zeevaart, JanRijn Maes, Alex Ebenhan, Thomas Van de Wiele, Christophe Eur J Nucl Med Mol Imaging Original Article BACKGROUND: To report on imaging findings using (68)Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. METHODS: (68)Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. RESULTS: Out of 81 tumor lesions identified, 84% were identified on (68)Ga-PSMA-HBED-CC PET. (68)Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and (68)Ga-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015). CONCLUSIONS: (68)Ga-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry. Springer Berlin Heidelberg 2016-11-08 2017 /pmc/articles/PMC5323468/ /pubmed/27822700 http://dx.doi.org/10.1007/s00259-016-3563-6 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Sathekge, Mike Lengana, Thabo Modiselle, Moshe Vorster, Mariza Zeevaart, JanRijn Maes, Alex Ebenhan, Thomas Van de Wiele, Christophe (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title | (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title_full | (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title_fullStr | (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title_full_unstemmed | (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title_short | (68)Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients |
title_sort | (68)ga-psma-hbed-cc pet imaging in breast carcinoma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323468/ https://www.ncbi.nlm.nih.gov/pubmed/27822700 http://dx.doi.org/10.1007/s00259-016-3563-6 |
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