Sequential Double “Clicks” toward Structurally Well‐Defined Heterogeneous N‐Glycoclusters: The Importance of Cluster Heterogeneity on Pattern Recognition In Vivo

Structurally well‐defined heterogeneous N‐glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ‐select...

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Detalles Bibliográficos
Autores principales: Latypova, Liliya, Sibgatullina, Regina, Ogura, Akihiro, Fujiki, Katsumasa, Khabibrakhmanova, Alsu, Tahara, Tsuyoshi, Nozaki, Satoshi, Urano, Sayaka, Tsubokura, Kazuki, Onoe, Hirotaka, Watanabe, Yasuyoshi, Kurbangalieva, Almira, Tanaka, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323863/
https://www.ncbi.nlm.nih.gov/pubmed/28251056
http://dx.doi.org/10.1002/advs.201600394
Descripción
Sumario:Structurally well‐defined heterogeneous N‐glycoclusters are prepared on albumin via a double click procedure. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, plays an important role in the in vivo kinetics and organ‐selective accumulation through glycan pattern recognition mechanisms. [Image: see text]

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