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Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism

OBJECTIVE: Variants in Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) may be causative for obesity as suggested by monogenic cases and association studies. Here we assessed the functional relevance in experimental studies and the clinical relevance through detailed metabolic phenotyping of ne...

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Detalles Bibliográficos
Autores principales:	Löffler, Dennis, Behrendt, Susanne, Creemers, John W.M., Klammt, Jürgen, Aust, Gabriela, Stanik, Juraj, Kiess, Wieland, Kovacs, Peter, Körner, Antje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323889/ https://www.ncbi.nlm.nih.gov/pubmed/28271036 http://dx.doi.org/10.1016/j.molmet.2016.12.002

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