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High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting
OBJECTIVE: α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323890/ https://www.ncbi.nlm.nih.gov/pubmed/28271030 http://dx.doi.org/10.1016/j.molmet.2017.01.003 |