A Transcriptional Profile of Aging in the Human Kidney

In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with...

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Detalles Bibliográficos
Autores principales: Rodwell, Graham E. J, Sonu, Rebecca, Zahn, Jacob M, Lund, James, Wilhelmy, Julie, Wang, Lingli, Xiao, Wenzhong, Mindrinos, Michael, Crane, Emily, Segal, Eran, Myers, Bryan D, Brooks, James D, Davis, Ronald W, Higgins, John, Owen, Art B, Kim, Stuart K
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC532391/
https://www.ncbi.nlm.nih.gov/pubmed/15562319
http://dx.doi.org/10.1371/journal.pbio.0020427
Descripción
Sumario:In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.

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