Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function

The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regi...

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Detalles Bibliográficos
Autores principales: Sherwood, Nina Tang, Sun, Qi, Xue, Mingshan, Zhang, Bing, Zinn, Kai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC532392/
https://www.ncbi.nlm.nih.gov/pubmed/15562320
http://dx.doi.org/10.1371/journal.pbio.0020429

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