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Endocytic Trafficking at the Mature Podocyte Slit Diaphragm

Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subseque...

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Autor principal: Swiatecka-Urban, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324021/
https://www.ncbi.nlm.nih.gov/pubmed/28286744
http://dx.doi.org/10.3389/fped.2017.00032
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author Swiatecka-Urban, Agnieszka
author_facet Swiatecka-Urban, Agnieszka
author_sort Swiatecka-Urban, Agnieszka
collection PubMed
description Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for degradation or recycled back to the plasma membrane. The slit diaphragm is a modified tight junction connecting foot processes of the glomerular epithelial cells, podocytes. Signaling at the slit diaphragm plays a critical role in the kidney while its dysfunction leads to glomerular protein loss (proteinuria), manifesting as nephrotic syndrome, a rare condition with an estimated incidence of 2–4 new cases per 100,000 each year. Relatively little is known about the role of endocytic trafficking in podocyte signaling and maintenance of the slit diaphragm integrity. This review will focus on the role of endocytic trafficking at the mature podocyte slit diaphragm.
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spelling pubmed-53240212017-03-10 Endocytic Trafficking at the Mature Podocyte Slit Diaphragm Swiatecka-Urban, Agnieszka Front Pediatr Pediatrics Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for degradation or recycled back to the plasma membrane. The slit diaphragm is a modified tight junction connecting foot processes of the glomerular epithelial cells, podocytes. Signaling at the slit diaphragm plays a critical role in the kidney while its dysfunction leads to glomerular protein loss (proteinuria), manifesting as nephrotic syndrome, a rare condition with an estimated incidence of 2–4 new cases per 100,000 each year. Relatively little is known about the role of endocytic trafficking in podocyte signaling and maintenance of the slit diaphragm integrity. This review will focus on the role of endocytic trafficking at the mature podocyte slit diaphragm. Frontiers Media S.A. 2017-02-24 /pmc/articles/PMC5324021/ /pubmed/28286744 http://dx.doi.org/10.3389/fped.2017.00032 Text en Copyright © 2017 Swiatecka-Urban. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Swiatecka-Urban, Agnieszka
Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title_full Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title_fullStr Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title_full_unstemmed Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title_short Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
title_sort endocytic trafficking at the mature podocyte slit diaphragm
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324021/
https://www.ncbi.nlm.nih.gov/pubmed/28286744
http://dx.doi.org/10.3389/fped.2017.00032
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