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Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy

The microtubule-associated protein tau is implicated in various neurodegenerative diseases including Alzheimer’s disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. Mutations in the tau gene MAPT cau...

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Detalles Bibliográficos
Autores principales:	Wobst, Heike J., Denk, Franziska, Oliver, Peter L., Livieratos, Achilleas, Taylor, Tonya N., Knudsen, Maria H., Bengoa-Vergniory, Nora, Bannerman, David, Wade-Martins, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324134/ https://www.ncbi.nlm.nih.gov/pubmed/28233851 http://dx.doi.org/10.1038/srep43198

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