An avoidable cause of thymoglobulin anaphylaxis

BACKGROUND: Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare. CASE PRESENTATION: We report a case of serious ana...

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Autores principales: Brabant, S., Facon, A., Provôt, F., Labalette, M., Wallaert, B., Chenivesse, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324248/
https://www.ncbi.nlm.nih.gov/pubmed/28250777
http://dx.doi.org/10.1186/s13223-017-0186-9
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author Brabant, S.
Facon, A.
Provôt, F.
Labalette, M.
Wallaert, B.
Chenivesse, C.
author_facet Brabant, S.
Facon, A.
Provôt, F.
Labalette, M.
Wallaert, B.
Chenivesse, C.
author_sort Brabant, S.
collection PubMed
description BACKGROUND: Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare. CASE PRESENTATION: We report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin during renal transplantation in a patient with undiagnosed respiratory allergy to rabbit allergens. CONCLUSIONS: This case report reinforces the importance of identifying rabbit allergy by a simple combination of clinical interview followed by confirmatory skin testing or blood tests of all patients prior to injection of thymoglobulin, which is formally contraindicated in patients with a history of hypersensitivity to rabbit proteins.
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spelling pubmed-53242482017-03-01 An avoidable cause of thymoglobulin anaphylaxis Brabant, S. Facon, A. Provôt, F. Labalette, M. Wallaert, B. Chenivesse, C. Allergy Asthma Clin Immunol Case Report BACKGROUND: Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare. CASE PRESENTATION: We report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin during renal transplantation in a patient with undiagnosed respiratory allergy to rabbit allergens. CONCLUSIONS: This case report reinforces the importance of identifying rabbit allergy by a simple combination of clinical interview followed by confirmatory skin testing or blood tests of all patients prior to injection of thymoglobulin, which is formally contraindicated in patients with a history of hypersensitivity to rabbit proteins. BioMed Central 2017-02-23 /pmc/articles/PMC5324248/ /pubmed/28250777 http://dx.doi.org/10.1186/s13223-017-0186-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Brabant, S.
Facon, A.
Provôt, F.
Labalette, M.
Wallaert, B.
Chenivesse, C.
An avoidable cause of thymoglobulin anaphylaxis
title An avoidable cause of thymoglobulin anaphylaxis
title_full An avoidable cause of thymoglobulin anaphylaxis
title_fullStr An avoidable cause of thymoglobulin anaphylaxis
title_full_unstemmed An avoidable cause of thymoglobulin anaphylaxis
title_short An avoidable cause of thymoglobulin anaphylaxis
title_sort avoidable cause of thymoglobulin anaphylaxis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324248/
https://www.ncbi.nlm.nih.gov/pubmed/28250777
http://dx.doi.org/10.1186/s13223-017-0186-9
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