Extracellular vesicles-mediated noncoding RNAs transfer in cancer

Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRNAs, long noncoding RNAs, and circular RNAs. Emerging evidence shows that EV-associated ncRN...

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Autores principales: Ma, Pei, Pan, Yutian, Li, Wei, Sun, Chongqi, Liu, Jie, Xu, Tongpeng, Shu, Yongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324273/
https://www.ncbi.nlm.nih.gov/pubmed/28231804
http://dx.doi.org/10.1186/s13045-017-0426-y
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author Ma, Pei
Pan, Yutian
Li, Wei
Sun, Chongqi
Liu, Jie
Xu, Tongpeng
Shu, Yongqian
author_facet Ma, Pei
Pan, Yutian
Li, Wei
Sun, Chongqi
Liu, Jie
Xu, Tongpeng
Shu, Yongqian
author_sort Ma, Pei
collection PubMed
description Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRNAs, long noncoding RNAs, and circular RNAs. Emerging evidence shows that EV-associated ncRNAs play important roles in a wide range of diseases, particularly in cancer where they function through regulating protein expression of the pivotal genes that make contributions to tumorigenesis. Given their stability and abundance in serum, EV-associated ncRNAs can act as new diagnostic biomarkers and new therapeutic targets for cancer. Herein, we review the properties of EV-associated ncRNAs, their functions, and potential significance in cancer.
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spelling pubmed-53242732017-03-01 Extracellular vesicles-mediated noncoding RNAs transfer in cancer Ma, Pei Pan, Yutian Li, Wei Sun, Chongqi Liu, Jie Xu, Tongpeng Shu, Yongqian J Hematol Oncol Review Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRNAs, long noncoding RNAs, and circular RNAs. Emerging evidence shows that EV-associated ncRNAs play important roles in a wide range of diseases, particularly in cancer where they function through regulating protein expression of the pivotal genes that make contributions to tumorigenesis. Given their stability and abundance in serum, EV-associated ncRNAs can act as new diagnostic biomarkers and new therapeutic targets for cancer. Herein, we review the properties of EV-associated ncRNAs, their functions, and potential significance in cancer. BioMed Central 2017-02-23 /pmc/articles/PMC5324273/ /pubmed/28231804 http://dx.doi.org/10.1186/s13045-017-0426-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ma, Pei
Pan, Yutian
Li, Wei
Sun, Chongqi
Liu, Jie
Xu, Tongpeng
Shu, Yongqian
Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title_full Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title_fullStr Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title_full_unstemmed Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title_short Extracellular vesicles-mediated noncoding RNAs transfer in cancer
title_sort extracellular vesicles-mediated noncoding rnas transfer in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324273/
https://www.ncbi.nlm.nih.gov/pubmed/28231804
http://dx.doi.org/10.1186/s13045-017-0426-y
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AT liujie extracellularvesiclesmediatednoncodingrnastransferincancer
AT xutongpeng extracellularvesiclesmediatednoncodingrnastransferincancer
AT shuyongqian extracellularvesiclesmediatednoncodingrnastransferincancer

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